CALL FOR PAPERS Innovative and Emerging Technologies in GI Physiology and Disease Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation
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چکیده
Jasmohan S. Bajaj, Phillip B. Hylemon, Jason M. Ridlon, Douglas M. Heuman, Kalyani Daita, Melanie B. White, Pamela Monteith, Nicole A. Noble, Masoumeh Sikaroodi, and Patrick M. Gillevet Division of Gastroenterology, Hepatology and Nutrition; Department of Microbiology, Virginia Commonwealth University and McGuire Veterans Affairs Medical Center, Richmond, Virginia; and Microbiome Analysis Center, George Mason University, Manassas, Virginia
منابع مشابه
Linkage of gut microbiome with cognition in hepatic encephalopathy.
Hepatic encephalopathy (HE) has been related to gut bacteria and inflammation in the setting of intestinal barrier dysfunction. We aimed to link the gut microbiome with cognition and inflammation in HE using a systems biology approach. Multitag pyrosequencing (MTPS) was performed on stool of cirrhotics and age-matched controls. Cirrhotics with/without HE underwent cognitive testing, inflammator...
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Genta Kakiyama, Phillip B. Hylemon, Huiping Zhou, William M. Pandak, Douglas M. Heuman, Dae Joong Kang, Hajime Takei, Hiroshi Nittono, Jason M. Ridlon, Michael Fuchs, Emily C. Gurley, Yun Wang, Runping Liu, Arun J. Sanyal, Patrick M. Gillevet, and Jasmohan S. Bajaj Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire Veterans Affairs Medical Cente...
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In recent years, the microbiome has been recognized as a key regulator of immune responses. Evidence suggests that changes in the microbiome can lead to chronic disease and even exacerbation of the disease. Impairment of innate immunity resulting from microbial incompatibility may worsen host susceptibility to infection and exacerbate chronic lung diseases. Specific microbes play a key role in ...
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Cirrhosis is a prevalent cause of morbidity and mortality, especially for those at an advanced decompensated stage. Cirrhosis development and progression involves several important interorgan communications, and recently, the gut microbiome has been implicated in pathophysiology of the disease. Dysbiosis, defined as a pathological change in the microbiome, has a variable effect on the compensat...
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Humans are almost identical in their genetic pattern, but the slight differences in our DNA lead to remarkable phenotypic variation among the human population. There are a variety of microbial communities and their genes (microbiomes) in the human body that play an essential role in human health and disease. The microbes inhabiting our bodies is quite a bit more variable, with only a third of i...
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تاریخ انتشار 2012